Clinical Characteristics of COVID-19: Clinical Dynamics of Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection Detected by Early Active Surveillance.
Identifieur interne : 000784 ( Main/Exploration ); précédent : 000783; suivant : 000785Clinical Characteristics of COVID-19: Clinical Dynamics of Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection Detected by Early Active Surveillance.
Auteurs : Hyeon Jeong Suh [Corée du Sud] ; Deok Hee Kim [Corée du Sud] ; Eun Young Heo [Corée du Sud] ; Hyun Woo Lee [Corée du Sud] ; Jung Kyu Lee [Corée du Sud] ; Chang Seop Lee [Corée du Sud] ; Mijeong Kim [Corée du Sud] ; Yong Duk Jeon [Corée du Sud] ; Jin Won Chung [Corée du Sud] ; Young Keun Kim [Corée du Sud] ; Pyo Jin Shin [Corée du Sud] ; Mi Suk Lee [Corée du Sud] ; Jin Suk Kang [Corée du Sud] ; Myung Jin Lee [Corée du Sud] ; Baek Nam Kim [Corée du Sud] ; Sang Won Park [Corée du Sud]Source :
- Journal of Korean medical science [ 1598-6357 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Charge virale (MeSH), Diagnostic précoce (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (traitement médicamenteux), Mâle (MeSH), Oxygène (usage thérapeutique), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (traitement médicamenteux), Réaction de polymérisation en chaine en temps réel (MeSH), Sujet âgé (MeSH).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
- usage thérapeutique : Oxygène.
- Adulte, Adulte d'âge moyen, Betacoronavirus, Charge virale, Diagnostic précoce, Femelle, Humains, Mâle, Pandémies, Réaction de polymérisation en chaine en temps réel, Sujet âgé.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Early Diagnosis (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Oxygen (therapeutic use), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (drug therapy), Real-Time Polymerase Chain Reaction (MeSH), Viral Load (MeSH).
- MESH :
- chemical , therapeutic use : Oxygen.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- drug therapy : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Betacoronavirus, Early Diagnosis, Female, Humans, Male, Middle Aged, Pandemics, Real-Time Polymerase Chain Reaction, Viral Load.
Abstract
BACKGROUND
There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. This study is a case series of patients with coronavirus disease 2019 (COVID-19) admitted to 11 hospitals in Korea.
METHODS
Patients with confirmed SARS-CoV-2 infection by positive polymerase chain reaction (PCR) testing of respiratory specimens by active surveillance that were finally discharged between February 20 and April 30, 2020 were included. Patients were classified into mild and non-mild groups on initial admission according to oxygen demand and Sequential Organ Failure Assessment score, and the mild group was followed up and subgrouped into non-aggravation and aggravation groups.
RESULTS
A total of 161 patients with SARS-CoV2 infection were enrolled. Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. Fever (odds ratio [OR], 4.56), thrombocytopenia (OR, 12.87), fever (OR, 27.22) and lactate dehydrogenase (LDH) > 300 U/L (OR, 18.35), and CRP > 1 mg/dL (OR, 11.31) significantly indicated aggravation in the 1st, 2nd, 3rd, and 4th 5-day periods, respectively. PCR positivity lasted for a median of 22 days and 32 days after the onset of illness in the non-aggravation and aggravation groups, respectively.
CONCLUSION
Old age was associated with early severe presentation. Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course.
DOI: 10.3346/jkms.2020.35.e297
PubMed: 32808513
PubMed Central: PMC7431284
Affiliations:
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Le document en format XML
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Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Chang Seop" sort="Lee, Chang Seop" uniqKey="Lee C" first="Chang Seop" last="Lee">Chang Seop Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju</wicri:regionArea><wicri:noRegion>Jeonju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Mijeong" sort="Kim, Mijeong" uniqKey="Kim M" first="Mijeong" last="Kim">Mijeong Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Suwon Hospital, Suwon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Gyeonggi Provincial Medical Center Suwon Hospital, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Yong Duk" sort="Jeon, Yong Duk" uniqKey="Jeon Y" first="Yong Duk" last="Jeon">Yong Duk Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Jin Won" sort="Chung, Jin Won" uniqKey="Chung J" first="Jin Won" last="Chung">Jin Won Chung</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Chung-Ang University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Young Keun" sort="Kim, Young Keun" uniqKey="Kim Y" first="Young Keun" last="Kim">Young Keun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju</wicri:regionArea><wicri:noRegion>Wonju</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Pyo Jin" sort="Shin, Pyo Jin" uniqKey="Shin P" first="Pyo Jin" last="Shin">Pyo Jin Shin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Gangwon-do Wonju Medical Center, Wonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Gangwon-do Wonju Medical Center, Wonju</wicri:regionArea><wicri:noRegion>Wonju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Mi Suk" sort="Lee, Mi Suk" uniqKey="Lee M" first="Mi Suk" last="Lee">Mi Suk Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kyung Hee University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de 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type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek Nam" last="Kim">Baek Nam Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea. kimbn@paik.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. hswon1@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno 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Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Deok Hee" sort="Kim, Deok Hee" uniqKey="Kim D" first="Deok Hee" last="Kim">Deok Hee Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Paju Hospital, Paju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Gyeonggi Provincial Medical Center Paju Hospital, Paju</wicri:regionArea><wicri:noRegion>Paju</wicri:noRegion></affiliation></author><author><name sortKey="Heo, Eun Young" sort="Heo, Eun Young" uniqKey="Heo E" first="Eun Young" last="Heo">Eun Young Heo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Hyun Woo" sort="Lee, Hyun Woo" uniqKey="Lee H" first="Hyun Woo" last="Lee">Hyun Woo Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Jung Kyu" sort="Lee, Jung Kyu" uniqKey="Lee J" first="Jung Kyu" last="Lee">Jung Kyu Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Lee, Chang Seop" sort="Lee, Chang Seop" uniqKey="Lee C" first="Chang Seop" last="Lee">Chang Seop Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju</wicri:regionArea><wicri:noRegion>Jeonju</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Mijeong" sort="Kim, Mijeong" uniqKey="Kim M" first="Mijeong" last="Kim">Mijeong Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Suwon Hospital, Suwon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Gyeonggi Provincial Medical Center Suwon Hospital, Suwon</wicri:regionArea><wicri:noRegion>Suwon</wicri:noRegion></affiliation></author><author><name sortKey="Jeon, Yong Duk" sort="Jeon, Yong Duk" uniqKey="Jeon Y" first="Yong Duk" last="Jeon">Yong Duk Jeon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon</wicri:regionArea><wicri:noRegion>Chuncheon</wicri:noRegion></affiliation></author><author><name sortKey="Chung, Jin Won" sort="Chung, Jin Won" uniqKey="Chung J" first="Jin Won" last="Chung">Jin Won Chung</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Chung-Ang University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Young Keun" sort="Kim, Young Keun" uniqKey="Kim Y" first="Young Keun" last="Kim">Young Keun Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju</wicri:regionArea><wicri:noRegion>Wonju</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Pyo Jin" sort="Shin, Pyo Jin" uniqKey="Shin P" first="Pyo Jin" last="Shin">Pyo Jin Shin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Gangwon-do Wonju Medical Center, Wonju, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Gangwon-do Wonju Medical Center, Wonju</wicri:regionArea><wicri:noRegion>Wonju</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Mi Suk" sort="Lee, Mi Suk" uniqKey="Lee M" first="Mi Suk" last="Lee">Mi Suk Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Kyung Hee University Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, Jin Suk" sort="Kang, Jin Suk" uniqKey="Kang J" first="Jin Suk" last="Kang">Jin Suk Kang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Inje University Busan Paik Hospital, Busan</wicri:regionArea><wicri:noRegion>Busan</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Myung Jin" sort="Lee, Myung Jin" uniqKey="Lee M" first="Myung Jin" last="Lee">Myung Jin Lee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek Nam" last="Kim">Baek Nam Kim</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea. kimbn@paik.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. hswon1@snu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Early Diagnosis (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Oxygen (therapeutic use)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (drug therapy)</term><term>Real-Time Polymerase Chain Reaction (MeSH)</term><term>Viral Load (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Charge virale (MeSH)</term><term>Diagnostic précoce (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Mâle (MeSH)</term><term>Oxygène (usage thérapeutique)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Réaction de polymérisation en chaine en temps réel (MeSH)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Oxygène</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Betacoronavirus</term><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Real-Time Polymerase Chain Reaction</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Charge virale</term><term>Diagnostic précoce</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. This study is a case series of patients with coronavirus disease 2019 (COVID-19) admitted to 11 hospitals in Korea.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Patients with confirmed SARS-CoV-2 infection by positive polymerase chain reaction (PCR) testing of respiratory specimens by active surveillance that were finally discharged between February 20 and April 30, 2020 were included. Patients were classified into mild and non-mild groups on initial admission according to oxygen demand and Sequential Organ Failure Assessment score, and the mild group was followed up and subgrouped into non-aggravation and aggravation groups.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 161 patients with SARS-CoV2 infection were enrolled. Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. Fever (odds ratio [OR], 4.56), thrombocytopenia (OR, 12.87), fever (OR, 27.22) and lactate dehydrogenase (LDH) > 300 U/L (OR, 18.35), and CRP > 1 mg/dL (OR, 11.31) significantly indicated aggravation in the 1st, 2nd, 3rd, and 4th 5-day periods, respectively. PCR positivity lasted for a median of 22 days and 32 days after the onset of illness in the non-aggravation and aggravation groups, respectively.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Old age was associated with early severe presentation. Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32808513</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>32</Issue><PubDate><Year>2020</Year><Month>Aug</Month><Day>17</Day></PubDate></JournalIssue><Title>Journal of Korean medical science</Title><ISOAbbreviation>J Korean Med Sci</ISOAbbreviation></Journal><ArticleTitle>Clinical Characteristics of COVID-19: Clinical Dynamics of Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection Detected by Early Active Surveillance.</ArticleTitle><Pagination><MedlinePgn>e297</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e297</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is limited information describing the presenting characteristics and dynamic clinical changes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosed in the early phase of illness. This study is a case series of patients with coronavirus disease 2019 (COVID-19) admitted to 11 hospitals in Korea.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients with confirmed SARS-CoV-2 infection by positive polymerase chain reaction (PCR) testing of respiratory specimens by active surveillance that were finally discharged between February 20 and April 30, 2020 were included. Patients were classified into mild and non-mild groups on initial admission according to oxygen demand and Sequential Organ Failure Assessment score, and the mild group was followed up and subgrouped into non-aggravation and aggravation groups.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 161 patients with SARS-CoV2 infection were enrolled. Among the mild group of 136 patients, 11.7% of patients experienced clinical aggravation during hospitalization, but there was no initial clinical parameter on admission predicting their aggravation. Fever (odds ratio [OR], 4.56), thrombocytopenia (OR, 12.87), fever (OR, 27.22) and lactate dehydrogenase (LDH) > 300 U/L (OR, 18.35), and CRP > 1 mg/dL (OR, 11.31) significantly indicated aggravation in the 1st, 2nd, 3rd, and 4th 5-day periods, respectively. PCR positivity lasted for a median of 22 days and 32 days after the onset of illness in the non-aggravation and aggravation groups, respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Old age was associated with early severe presentation. Clinical aggravation among asymptomatic or mild patients could not be predicted initially but was heralded by fever and several laboratory markers during the clinical course.</AbstractText><CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Suh</LastName><ForeName>Hyeon Jeong</ForeName><Initials>HJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7289-9586</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Deok Hee</ForeName><Initials>DH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7593-7461</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Paju Hospital, Paju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heo</LastName><ForeName>Eun Young</ForeName><Initials>EY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-3803-4903</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Hyun Woo</ForeName><Initials>HW</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4379-0260</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jung Kyu</ForeName><Initials>JK</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5060-7255</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Chang Seop</ForeName><Initials>CS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2897-2202</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Mijeong</ForeName><Initials>M</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4456-206X</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Suwon Hospital, Suwon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Yong Duk</ForeName><Initials>YD</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4588-4781</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Jin Won</ForeName><Initials>JW</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4811-6056</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Young Keun</ForeName><Initials>YK</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-2120-6265</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Pyo Jin</ForeName><Initials>PJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4692-8878</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Gangwon-do Wonju Medical Center, Wonju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Mi Suk</ForeName><Initials>MS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8951-5032</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Jin Suk</ForeName><Initials>JS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4137-5453</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Myung Jin</ForeName><Initials>MJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-8172-8025</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Baek Nam</ForeName><Initials>BN</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5551-2132</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea. kimbn@paik.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Sang Won</ForeName><Initials>SW</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-0550-1897</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. hswon1@snu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>04-2020-0210</GrantID><Acronym>SNUH</Acronym><Agency>Seoul National University Hospital</Agency><Country>Korea</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Med Sci</MedlineTA><NlmUniqueID>8703518</NlmUniqueID><ISSNLinking>1011-8934</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042241" MajorTopicYN="N">Early Diagnosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Active Surveillance</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Korea</Keyword><Keyword MajorTopicYN="N">Mild</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList><CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32808513</ArticleId><ArticleId IdType="pii">35.e297</ArticleId><ArticleId IdType="doi">10.3346/jkms.2020.35.e297</ArticleId><ArticleId 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last="Heo">Eun Young Heo</name><name sortKey="Heo, Eun Young" sort="Heo, Eun Young" uniqKey="Heo E" first="Eun Young" last="Heo">Eun Young Heo</name><name sortKey="Jeon, Yong Duk" sort="Jeon, Yong Duk" uniqKey="Jeon Y" first="Yong Duk" last="Jeon">Yong Duk Jeon</name><name sortKey="Kang, Jin Suk" sort="Kang, Jin Suk" uniqKey="Kang J" first="Jin Suk" last="Kang">Jin Suk Kang</name><name sortKey="Kim, Baek Nam" sort="Kim, Baek Nam" uniqKey="Kim B" first="Baek Nam" last="Kim">Baek Nam Kim</name><name sortKey="Kim, Deok Hee" sort="Kim, Deok Hee" uniqKey="Kim D" first="Deok Hee" last="Kim">Deok Hee Kim</name><name sortKey="Kim, Mijeong" sort="Kim, Mijeong" uniqKey="Kim M" first="Mijeong" last="Kim">Mijeong Kim</name><name sortKey="Kim, Young Keun" sort="Kim, Young Keun" uniqKey="Kim Y" first="Young Keun" last="Kim">Young Keun Kim</name><name sortKey="Lee, Chang Seop" sort="Lee, Chang Seop" uniqKey="Lee C" first="Chang Seop" last="Lee">Chang Seop Lee</name><name sortKey="Lee, Hyun Woo" sort="Lee, Hyun Woo" uniqKey="Lee H" first="Hyun Woo" last="Lee">Hyun Woo Lee</name><name sortKey="Lee, Hyun Woo" sort="Lee, Hyun Woo" uniqKey="Lee H" first="Hyun Woo" last="Lee">Hyun Woo Lee</name><name sortKey="Lee, Jung Kyu" sort="Lee, Jung Kyu" uniqKey="Lee J" first="Jung Kyu" last="Lee">Jung Kyu Lee</name><name sortKey="Lee, Jung Kyu" sort="Lee, Jung Kyu" uniqKey="Lee J" first="Jung Kyu" last="Lee">Jung Kyu Lee</name><name sortKey="Lee, Mi Suk" sort="Lee, Mi Suk" uniqKey="Lee M" first="Mi Suk" last="Lee">Mi Suk Lee</name><name sortKey="Lee, Myung Jin" sort="Lee, Myung Jin" uniqKey="Lee M" first="Myung Jin" last="Lee">Myung Jin Lee</name><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang Won" last="Park">Sang Won Park</name><name sortKey="Shin, Pyo Jin" sort="Shin, Pyo Jin" uniqKey="Shin P" first="Pyo Jin" last="Shin">Pyo Jin Shin</name><name sortKey="Suh, Hyeon Jeong" sort="Suh, Hyeon Jeong" uniqKey="Suh H" first="Hyeon Jeong" last="Suh">Hyeon Jeong Suh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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